XIAP与Apaf-1在鼻内翻性乳头状瘤癌变中的表达及意义
Expression and significance of XIAP and Apaf 1 in the carcinogenesis of nasal inverted papilloma
范宗宪 1王海燕 2王世军 1杨琳红 1朱劲松 1樊淑华 1霍海峰1
作者信息
- 1. 佳木斯大学附属第一医院耳鼻咽喉科,黑龙江佳木斯154003
- 2. 河北省沧州市中心医院
- 折叠
摘要
目的 探讨x-连锁凋亡抑制蛋白(XIAP)与凋亡蛋白酶活化因子-1(Apaf-1)在鼻内翻性乳头状瘤(NIP)发生发展及其恶变过程中的作用.方法 采用兔抗人XIAP多克隆抗体和兔抗人Apaf-1多克隆抗体,应用免疫组化方法检测15例NIP伴癌变组织中XIAP与Apaf-1的表达.结果 (1)XIAP在NIP、NIP伴癌变、NSCC中的表达结果分别为56％、86.6％、90％,差异有统计学意义(P＜0.05); (2)Apaf-1在NIP、NIP伴癌变、NSCC中表达结果分别为60％、6.6％、20％,差异有统计学意义(P＜0.05).结论 检测XIAP与Apaf-1可作为判断NIP是否发生恶变的重要指标.
Abstract
Objective To explore the expression of X-linked inhibitor apoptosis protein (XIAP) and apoptosis protease activating factor-1 (Apaf-1) in nasal inverted papilloma (NIP), and explore their function in the development and malignant change process of NIP. Methods Immunohistochemical method was used to detect the expressions of XIAP and Apaf 1 in 15 samples of the NIP with carcinomatous tissue. Results (1 )The positive rate of XIAP protein expression was respectively 86. 6%S56% and 90% in NIP, NIP with carcinomatous and NSCC, which was significantly deviated (P<0. 05). (2)The positive rate of Apaf 1 protein expression was respectively 60% ,6. 6% and 20% in NIP, NIP with carcinomatous and NSCC, which was significantly deviated (P<0. 05). Conclusions The detection of XIAP and Apaf 1 may be an important indicator for judging NIPs malignant change or not. MeSH:Nose Neoplasms/metabolism; Papilloma/metabolism; X-Linked Inhibitor of Apoptosis Protein/metabolism;
关键词
鼻肿瘤/代谢/乳头状瘤/代谢/X连锁凋亡抑制蛋白质/代谢/凋亡蛋白酶活化因子1/代谢Key words
Protease-Activating Factor I/metabolism引用本文复制引用
基金项目
黑龙江省卫生厅科研课题(2010-488)
出版年
2012
NETL
NSTL
维普
万方数据