The difference of EphA4 expression between wild strain and resistant strain of K562 cells
Objective To lay the foundation for the role of EphA4 in the development of leukemia by observation of the EphA4 gene expression in wild strain and resistant strain of K562 cells. Methods EphA4 gene expression in wild strain and resistant strain of K562 cells were detected quantitatively with real-time fluorescence quantitative reverse transcription polyraerase chain reaction (QRT-PCR). Resolts The difference of EphA4 gene expression between wild type K56Z cells and resistant type K562 cells was statistically significant (P<0.01),and the EphA4 gene expression in the wild strain of K562 cells was significantly higher than that in resistant strains of K562 cells. Conclusion We make a conclusion that it is meaningful for the study of mechanism, pathological evolution,clinical manifestations and prognosis of chronic myeloid leukemia based on the significant difference of EphA4 gene expression between wild strains and resistant strains of K562 cells.
NETL
NSTL
万方数据
维普
