Effect of valsartan on cardiac function and structure in maintenance hemodialysis patients
Objective To study valsartan on cardiac (unction and structure in maintenance hemodialysis (MHD) patients. Methods 100 MHD patients were randomized into valsartan group and control group. Patients in the valsartan group were given 80mg valsartan per day for six months. Before and after the treatment, cardiac structure echo-cardiography Index: Left atrial end systolic diameter (LADs), left ventricular end diastolic diameter (LVEDd), tn-terventricular septum diastolic thickness (IVSTd), left ventricular posterior wall diastolic thickness (LVPWTd), left atrial diameter index (LAI), left ventricular mass index ( LVMI), relative wall thickness (RWT), cardiac function parameters: the cardiac function parameters, such as left ventricular ejection fraction (LVEF), left ventricular fractional shortening (KS) .mitral early and late diastolic peak velocity ratio (E/A) .were detected with echocardio-graphy. The data were statistically analyzed through SPSS16. 0. Results After 6 months, MHD patients with the treatment group cardiac structure indicators:LADs, LVEDd, IVSTd, LVPWTd, LAI, LVMI values were significantly lower than the control group,the difference was significant (P<0. 05), RWT had no significant difference) P >0. 05). Indicators of cardiac function: LVEF, FS, E/A values were significantly higher than the control group, the difference was significant (P <0. 05). Conclusions Valsartan can improve cardiac function and structure in MHD patients, and maybe contribute to the prevention and treatment of cardiovascular complications in MHD patients.
NETL
NSTL
万方数据
维普
