MRI diagnosis of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes
Objective To investigate the characteristic of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) on MRI. Method 10 patients with MELAS confirmed by pathological examination were retrospectively analyzed and undertook MRI examination. Results All the 10 patients had lesions of multiple lobes. Brain parenchymal lesions in all patients were low intensity on T1WI and high signal intensity on T2WI. Five patients had double prefrontal lobe.parietooccipital cortex involvement , while involvement of right frontal pole.pre-frontal lobe,occipital pole were observed in 3 patients, and two patients had left prefrontal lobe,occipital cortex involvement. All the patients had lesions which were not in consistence with the distribution of intracranial vessels. Brain parenchymal lesions were high intensity on FLAIR and high signal intensity on DWI in acute phase. There were three patients had deep brain nucleus involvement,two had lentiform nucleus involvement,and one had lenti-form nucleus and caudate nucleus involvement. Two patients had cerebellar involvement, while involvement of brainstem was observed in 1 patients, and four patients had brain atrophy, only few was enhanced on MRI enhancement scanning. Conclusion MRI appearance of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes(MELAS) have some characteristics. If we connect tightly clinical appearance,laboratory results with MRI manifestation, accuracy of diagnosis can be highly increased.
NETL
NSTL
万方数据
维普
