Comparison of effect between Metformin and Acarbose in treatment of type 2 diabetes mellitus with early diabetic nephropathy
Objective To compare the effects of metformin and acarbose for early diabetic nephropathy. Methods 122 cases of type 2 diabetic mellitus (T2DM) with early diabetic nephropathy were randomly devided into Metformin group including 58 cases treated with Metformin and Acarbose group including 59 cases treated with Acarbose for 24 weeks. Two groups' parameters including blood pressure (BP), fasting glucose (FPG}, glycosylated hemoglobin C (HbAlc), HOMA-IR, high sensitivity C-reactive protein( Hs-CRP) and urinary albumin excretory rate(UAER) were observed before and after therapy. Results FPG and HbAlc were significantly declined in both groups. Compared with Acarbose group.BP.HOMA-IR.Hs-CRP.UAER were significantly decreased in Metformin group.Conclusion For the T2DM with early diabetic nephropathy,Metformin can reduce UAER better than Acarbose.
Diabetic Nephropathiesdrug therapyMetformintherapeutic useAcarbosetherapeutic use
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万方数据
维普
