Relationship between matrix metalloproteinase-2, testosterone(TES),estradiol and hyperlipidemia and carotid atherosclerosis
Objective To explore the correlation between matrix metalloproteinase-2,testosterone(TES),estradiol and hyperlipidemia and carotid atherosclerosis. Methods 146 patients were investigated and divided into three group:by the nature of ultrasonography of carotid atherosclerosis plaque and blood lipids levels: hyperlipaemia with plaque group(group A) 45 cases,hyperlipaemia without plaque group(group B) 41 cases,normal lipidemia group(group C) 60 cases. Color Doppler Ultrasonography was performed to detect the level of carotid intima - media thickness (IMT). ELIEA was uses to evaluated serum MMP-2 and CLIA was used to evaluatged serlon TES and estradid. Serum TES and estradiol were evaluated using Chemiluminescence Immunoassay(CLIA). Resnlls Serum MMP-2 concentration were significantly elevated in group A,comparing with that in group B and C(P<0.05),but there was no statistical difference between group B and C. The concentration of serum TES and estradiol in group A were lower than that in group B and C,and the concentration in group B was lower than that in group C as well. In addition,the concentration of serum TES and estradiol reflected dramatic statistical difference in three groups( P<0. 05). To sum up,the concentration of serum MMP-2 had a negative relation to that of TES and estradiol in A and B group(r= - 0.597 ,P<0.01 in group A and r=- 0. 622, P<0. 05 in group B). Conclusion The concentration of serum MMP-2,TES and estradiol has a relation to hyperlipaemia and carotid atherosclerosis.
NETL
NSTL
万方数据
维普
