血清MMP-2、TES、E2与高血脂及颈动脉粥样硬化的关系
Relationship between matrix metalloproteinase-2, testosterone(TES),estradiol and hyperlipidemia and carotid atherosclerosis
林文源 1余传坤 1林沐 1王志萍 1高小瞻 1熊光润1
作者信息
- 1. 宜昌第二人民医院,湖北宜昌443000
- 折叠
摘要
目的 探讨血清基质金属蛋白酶(MMP-2)、睾酮(TES)、雌二醇(E2)与高血脂及颈动脉粥样硬化的关系.方法 对146例患者分别进行血脂测定、颈动脉超声检查,测定并记录颈动脉内中膜厚度(IMT)、斑块形态、回声强度、斑块数量.根据超声病理形态和血脂水平分为有斑块高血脂组(A组)45例、无斑块高血脂组(B组)41例和血脂正常组(C组)60例.采用酶联免疫双抗体夹心法(ELISA)测定患者血清MMP-2、化学发光法测定血清TES、E2水平.结果 血清MMP-2 A组高于B组和C组,差异有统计学意义(P＜0.05),而B组与C组无统计学差异;血清TES、E2 A组低于B组和C组、B组低于C组,差异有统计学意义(P＜0.05)；A组和B组血清MMP-2与TES、E2成负相关(r=-0.597,P＜0.05;r=-0.622,P＜0.05).结论 血清MMP-2、TES、E2水平与高血脂及颈动脉斑块有关.
Abstract
Objective To explore the correlation between matrix metalloproteinase-2,testosterone(TES),estradiol and hyperlipidemia and carotid atherosclerosis. Methods 146 patients were investigated and divided into three group:by the nature of ultrasonography of carotid atherosclerosis plaque and blood lipids levels: hyperlipaemia with plaque group(group A) 45 cases,hyperlipaemia without plaque group(group B) 41 cases,normal lipidemia group(group C) 60 cases. Color Doppler Ultrasonography was performed to detect the level of carotid intima - media thickness (IMT). ELIEA was uses to evaluated serum MMP-2 and CLIA was used to evaluatged serlon TES and estradid. Serum TES and estradiol were evaluated using Chemiluminescence Immunoassay(CLIA). Resnlls Serum MMP-2 concentration were significantly elevated in group A,comparing with that in group B and C(P<0.05),but there was no statistical difference between group B and C. The concentration of serum TES and estradiol in group A were lower than that in group B and C,and the concentration in group B was lower than that in group C as well. In addition,the concentration of serum TES and estradiol reflected dramatic statistical difference in three groups( P<0. 05). To sum up,the concentration of serum MMP-2 had a negative relation to that of TES and estradiol in A and B group(r= - 0.597 ,P<0.01 in group A and r=- 0. 622, P<0. 05 in group B). Conclusion The concentration of serum MMP-2,TES and estradiol has a relation to hyperlipaemia and carotid atherosclerosis.
关键词
基质金属蛋白酶2/血液/睾酮/血液/雌二醇/血液/高脂血症/血液/颈动脉疾病/血液Key words
Matrix Metalloproteinase'2/Blood/Testosterone/Blood/Estradiol/Blood/Hyperlipidemias/Blood/Carotid Artery Diseases/Blood引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据