Levels change and its clinical significance of high sensitivity C reactive protein and N terminal pro-brain natriuretic peptide of patients with coronary heart disease
Objective To detect the changes of N-terminal pro-brain natriuretic peptide(NT-proBNP)and high sensitivity C reactive proteinf hs-CRP) levels of patients with coronary heart disease and discuss its clinical significance. Methods We measured the serum levels of NT-proBNP and of hs-CRP from 120 cases of coronary artery disease, and 50 healthy controls. Analytical Performance Evaluation of The ROCHE E170 MODULAR 1MMUNOASS ANALYZER was used to detect NT-proBNP levels and Rate nephelometry immunoassay for hs-CRP measurement. Re-salts The median of hs-CRP in patients' serum with coronary heart disease was 5. 76(3. 65～18. 89)mg/L,abnormal rate of 35. 9% ,the median of hs-CRP in serum of healthy control group was 2. 82(0. 29 ～11. 6 )mg/L,abnormality rate was 11. 2% ,the two groups had significant difference(P<0. 01). NT-proBNP of coronary heart disease according to NYHA class, Ⅱ , Ⅲ ,Ⅳ level of serum were 1 260(380～1 560)Pg/ml,2 250(890~3 690)Pg/ml and 4 120(2 990～7 800)Pg/ml,Which were significantly higher than healthy controls NT-proBNP189(51～966)Pg/ml. Conclusion hs-CRP and NT-proBNP levels in the serum are increased with the severity of coronary heart disease and increased understanding for both the detection of cardiac function has important clinical significance.
NETL
NSTL
万方数据
维普
