冠心病患者超敏C反应蛋白及N端B型脑钠肽前体水平变化及临床意义
Levels change and its clinical significance of high sensitivity C reactive protein and N terminal pro-brain natriuretic peptide of patients with coronary heart disease
张光辉 1李忠信 1杨义明 2张瑞霞 2蒲荣3
作者信息
- 1. 东莞康华医院检验科,广东东莞523080
- 2. 上海交大第九人民医院奉城分院检验科
- 3. 东莞市寮步医院,广东东莞523400
- 折叠
摘要
目的 检测冠心病患者N末端B型脑钠肽前体(N-terminal pro-brain natriuretic peptide.NT-proBNP)及超敏CRP( high-sensitivity C-reactive protein,hs-CRP)水平的改变并探讨其临床意义.方法 选取明确诊断的冠心病患者120例,健康对照50例.NT-proBNP检测使用电化学发光法,hs-CRP检测使用速率散射比浊法.结果 冠心病患者组血清hs-CRP中位数为5.76(3.65～18.89) mg/L,异常率为35.9％,健康对照组血清hs-CRP中位数为2.82(0.29～11.6)mg/L,异常率为11.2％.两组比较,差异有统计学意义(P＜0.01).冠心病患者按照NYHA心功能分级,Ⅱ、Ⅲ、Ⅳ级血清NT-proBNP分别为1 260(380～1 560) Pg/ml、2 250(890～3 690) Pg/ml和4 120(2 990～7 800)Pg/ml.均显著高于健康对照组NT-proBNP 189( 51～966) Pg/ml.结论 血清hs-CRP和NT-proBNP水平均随着冠心病严重程度的加重而升高,二者的检测对于了解心功能状态具有重要临床意义.
Abstract
Objective To detect the changes of N-terminal pro-brain natriuretic peptide(NT-proBNP)and high sensitivity C reactive proteinf hs-CRP) levels of patients with coronary heart disease and discuss its clinical significance. Methods We measured the serum levels of NT-proBNP and of hs-CRP from 120 cases of coronary artery disease, and 50 healthy controls. Analytical Performance Evaluation of The ROCHE E170 MODULAR 1MMUNOASS ANALYZER was used to detect NT-proBNP levels and Rate nephelometry immunoassay for hs-CRP measurement. Re-salts The median of hs-CRP in patients' serum with coronary heart disease was 5. 76(3. 65～18. 89)mg/L,abnormal rate of 35. 9% ,the median of hs-CRP in serum of healthy control group was 2. 82(0. 29 ～11. 6 )mg/L,abnormality rate was 11. 2% ,the two groups had significant difference(P<0. 01). NT-proBNP of coronary heart disease according to NYHA class, Ⅱ , Ⅲ ,Ⅳ level of serum were 1 260(380～1 560)Pg/ml,2 250(890~3 690)Pg/ml and 4 120(2 990～7 800)Pg/ml,Which were significantly higher than healthy controls NT-proBNP189(51～966)Pg/ml. Conclusion hs-CRP and NT-proBNP levels in the serum are increased with the severity of coronary heart disease and increased understanding for both the detection of cardiac function has important clinical significance.
关键词
冠状动脉疾病/代谢/C反应蛋白质/分析/利钠肽,脑/血液Key words
Coronary Artery Disease/metabolism/C-Reactive Protein/Analysis/Natriuretic Peptide, Brain/Blood引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据