纳洛酮联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的效果
Research on effect of Monosialotetrahexosyl Ganglioside Sodium and Naloxone on neonatal hypoxic ischemic encephalopathy
刘一沉 1白侠 1陈巧云1
作者信息
- 1. 解放军第159中心医院小儿科,河南驻马店463000
- 折叠
摘要
目的 观察纳洛酮联合单唾液酸四己精神经节苷脂钠(GM1)治疗新生儿缺氯缺血性脑病(HIE)的临床疗效.方法 将120例HIE随机分为2组,2组均给予常规治疗,治疗组加用纳洛酮和GM1,比较两组临床症状消失及治疗前后新生儿行为神经测定(NBNA).结果 治疗组治疗有效率与对照组相比较,差异有统计学意义(P＜0.01).结论 纳洛酮、单唾液酸四己糖神经节苷脂钠(GM1)联合治疗HIE有协同作用,疗效良好,是HIE有效治疗方法之一.
Abstract
Objective To investigate the therapeutic effects of Monosialotetrahexosyl Ganglioside Sodium and Naloxone to treat neonatal hypoxic ischemic encephalopathy(HIE). Methods 120 cases of HIE were randomly divided into treatment group and control group. All patients were obtainted conventional therapy. Treatment group were given Monosialotetrahexosyl Ganglioside Sodium and Naloxone. The therapic effects and NBNA score were compared and analyzed. Results There were significiant differences on effective rate of the two groups(P<0.01). Conclusions It has effective effects on HIE for Monosialotetrahexosyl Ganglioside Sodium and Naloxone, which is an idea therapy method.
关键词
纳洛酮/治疗应用/G(M1)神经节苷脂/治疗应用/己糖类/治疗应用/唾液酸类/治疗应用/脑缺血/药物疗法/缺氧,脑/药物疗法/婴儿,新生,疾病/药物疗法Key words
Naloxone/therapeutic use/G(M1) Ganglioside/therapeutic use/Hexoses/therapeutic use/Sialic Acids/therapeutic use/Brain Ischemia/drug therapy/Hypoxia, Brain/drug therapy/Infant, Newborn, Diseases/drug therapy引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据