VEGF-D与舌鳞癌淋巴转移的相关性研究
Study of relationship between expression of VEGF-D and lymph metastasis in tongue squamous cell carcinoma
李青川 1李新明 2赵军方 2王海斌 2谢卫红 2方政2
作者信息
- 1. 解放军信息工程学院门诊部,河南郑州 450052
- 2. 郑州大学第一附属医院口腔科
- 折叠
摘要
目的 检测舌鳞癌组织中VEGF-D(血管内皮生长因子-D)蛋白的表达,分析推断VEGF-D在舌鳞癌淋巴转移中的作用.方法 应用免疫组化PV9000二步法检测69例舌鳞癌组织中VEGF-D蛋白的表达.结果 69例舌鳞癌中30例VEGF-D表达阳性,阳性率为43.48％,与对照组相比差异有统计学意义(P＜0.05).舌鳞癌患者淋巴结转移阳性组中VEGF-D蛋白表达显著高于无淋巴结转移舌鳞癌患者组(P＜0.05).结论 VEGF-D表达升高与淋巴转移有关.
Abstract
Objective To detect the expression levels of VEGF-D(vascular endothelial growth factor-D) in tongue squamous cell carcinoma. To analyse the possible mechanism of the VEGF-D of lymph node metastasis in tongue squamous cell carcinoma. Methods To research the expression of proteinum of VEGF-D in 69 cases of tongue squamous cell carcinoma by use oC immunohistochemistry of PV9000. Results The positive expression of VEGF-D in tongue squamous cell carcinoma was 43.48%. There was statistical difference of the positive expression rate of control group(P>0.05). The positive rate of VEGF-D in lymph node metastasis group were higher than those of non lymph node metastasis group(.P>0. 05). Conclusion The high expressive rate of VEGF-D proteinum is associated with lymph node metastasis.
关键词
血管内皮生长因子D/代谢/癌,鳞状细胞/代谢/舌肿瘤/代谢/淋巴转移Key words
Vascular Endothelial Growth Factor D/metabolism/Carcinoma, Squamous Cell/metabolism/Tongue Neoplasms/metabolism/Lymphatic Metastasis引用本文复制引用
出版年
2012
NETL
NSTL
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