Expression and significance of P57, P63 and Ki-67 in the placental villi with hydropic changes
Objective To investigate the expression and significance of P57, P63 and Ki-67 in the placental villi with hydropic changes. Methods 23 partial hydatidiform moles (PHM) patients, 20 complete hydatidiform moles (CHM) patients and 13 first trimester hydropic abortions patients were evaluated by means of immunohistochemical technique in this study. Results The results of immunohistochemical staining showed that P57 expression in cyto-trophoblasts was either absent (19 cases) or very low (1 case) in CHM. In contrast, in all PHM, nuclear PS7 was expressed in cytotrophoblasts and villous stromal cells (23/23). Meanwhile, P57 was moderately and strongly expressed in 13 cases. In the majority of hydropic abortions (11/13), P5 7 expression was observed. There was a significant difference between CHM and PHM, CHM and HA(P< 0. 01). The Ki-67 immunoreactivity was significantly higher in the hydatidiform moles group than in the abortion group with hydropic changes (P<0. 05). No matter the quantity of immunostaining or the intensity of immunostaining, there was no significant difference in expression of P63 among hydropic abortion, PHM and CHM. Conclusion Our findings suggest that expression of PS7 and Ki-67 can be used to differentiate between abortion with hydropic changes and hydatidiform moles when two markers are used together by means of immunohistochemical technique. The role of P63 in the placental vtUi with hydropic changes, however, further investigation is required.
NETL
NSTL
万方数据
维普
