Effect of analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients
Objective To observe the effect of labor analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients. Methods Two hundreds of labor women were divided into two groups with 100 cases each. One hundred parturients were selected as labor analgesia group(groupl)and the others were as nature delivery group without analgesia (groupll). Analgesia was used while utero-eervical was opened to 2～3 cm. The levels of serum inteileukin-6,interleukin-8 and interleukin-10 were observed at five time points:before labor analgesia ,at 2h after the labor analgesia , at 24 ,48 ,72h at the end of delivery. Results The levels of serum lL-6,IL-8 and IL-10 increased significantly after labor analgesia , reached at peak values at 24 h (P<0. 05) ,and then gradually declined but still than the baseline values. The serum IL-6 ,IL-8 and IL-10 were significantly higher at 2 and 24 h in groupl-Ithan those in groupl (P<0.05) .Conclusion Labor analgesia with continued epidural block is safe and effective . Epidural analgesia can reduce the level of serum interleukin-6,interleukin-8 and interleukin-10 and inflammatory response during delivery.
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