分娩镇痛对产妇血清IL-6、IL-8、IL-1O水平的影响
Effect of analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients
修玉芳 1黄东林 1肖龙 1张陆 1孙玉蕾2
作者信息
- 1. 大连市妇产医院麻醉科,辽宁大连116031
- 2. 中国医学科学院整形外科医院麻醉科,北京100144
- 折叠
摘要
目的 观察应用罗哌卡因连续硬膜外阻滞麻醉进行分娩镇痛对产妇血清中IL-6、IL-8、IL-10的影响.方法 选择200例产妇随机分为观察组(Ⅰ组)和对照组(Ⅱ组),每组100例.Ⅰ组在宫口开至2～3 cm时开始采用连续硬膜外阻滞麻醉方法进行分娩镇痛；Ⅱ组按产科常规处理.观察分娩镇痛前30 min、分娩镇痛后2h、分娩后24h、48 h和72 h五个时点患者血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素- 10( IL- 10)水平的变化.结果 两组患者分娩镇痛后血清1L-6、IL-8、IL-10水平与分娩镇痛前值比较均升高(P＜0.01),一般在分娩后24 h达峰值.比较血清IL-6、IL-8、IL-10浓度变化,Ⅱ组较Ⅰ组升高更为明显(P＜0.05).结论 应用罗哌卡因连续硬膜外阻滞麻醉进行分娩镇痛可有效地降低产妇分娩后炎性应激反应.
Abstract
Objective To observe the effect of labor analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients. Methods Two hundreds of labor women were divided into two groups with 100 cases each. One hundred parturients were selected as labor analgesia group(groupl)and the others were as nature delivery group without analgesia (groupll). Analgesia was used while utero-eervical was opened to 2～3 cm. The levels of serum inteileukin-6,interleukin-8 and interleukin-10 were observed at five time points:before labor analgesia ,at 2h after the labor analgesia , at 24 ,48 ,72h at the end of delivery. Results The levels of serum lL-6,IL-8 and IL-10 increased significantly after labor analgesia , reached at peak values at 24 h (P<0. 05) ,and then gradually declined but still than the baseline values. The serum IL-6 ,IL-8 and IL-10 were significantly higher at 2 and 24 h in groupl-Ithan those in groupl (P<0.05) .Conclusion Labor analgesia with continued epidural block is safe and effective . Epidural analgesia can reduce the level of serum interleukin-6,interleukin-8 and interleukin-10 and inflammatory response during delivery.
关键词
镇痛,产科/白细胞介素6/代谢/白细胞介素8/代谢/白细胞介素10/代谢Key words
Analgesia, Obstetrical/Interleukin-6/metabolism/Interleukin-8/metaboIism/Interleukin-10/metabolism引用本文复制引用
出版年
2012
NETL
NSTL
万方数据