替莫唑胺联合小剂量缓激肽对延长胶质瘤大鼠生存期的观察
Observe effects of Temozolomide combined with low dose Bradykinin in prolonging survival time of rat with glioma
于倩 1宋飞 2刘贺 1白莉娜1
作者信息
- 1. 大连医科大学附属第二医院干诊科 100623
- 2. 大连医科大学附属第二医院脑外科
- 折叠
摘要
目的 探讨替莫唑胺联合小剂量缓激肽对胶质瘤的治疗作用.方法 立体定向法建立大鼠C6胶质瘤模型,MRI检测胶质瘤生长情况.观察常规使用替莫唑胺及替莫唑胺联合小剂量缓激肽后C6胶质瘤大鼠的生存情况,不同组别大鼠的生存期进行统计学分析.结果 替莫唑胺可以有效延长C6胶质瘤大鼠的生存期,联合小剂量缓激肽后C6胶质瘤大鼠的生存期延长更显著.结论 替莫唑胺对胶质瘤有治疗作用,小剂量缓激肽可以选择性开放血脑屏障,替莫唑胺联合小剂量缓激肽可以有效治疗胶质瘤,延长大鼠生存期.
Abstract
Objective To investigate the effect of Temozolomide combined with low dose Bradykinin for glioma therapy. Methods To use the stereotactic method to establish the C6 glioma model rats,and lest the glioma growth by MRI. Observerd the survival condition of the models treated with Temozolomide and Temozolomide with low dose Bradykinin,studied the survival times in different groups by statistical analysis. Resnlts Temozolomide could prolong the survival times of the models,and prolonged more signally after treated with low dose Bradykinin. Conclusion Temozolomide has curative effect for glioma,low dose Bradykinin can open blood brain barrier,temozolomide combined with low dose Bradykinin can treat glioma effectively,prolong the survival times of the rat models.
关键词
莫唑胺/治疗应用/缓激肽/投药和剂量/神经胶质瘤/药物疗法/疾病模型,动物Key words
Muzolimine/therapeutic use/Bradykinin/administration & dosage/Glioma/drug therapy/Disease Models, Animal引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据