Study on immuno-phenotype in early diagnosis of myelodysplastic syndrome
Objective To research the immuno-phenotype's significance in the classification and differentiation of myelodysplastic syndrome( MDS). Methods The immuno-phenotype of bone marrow cells was detected in 98 patients with MDS and 100 patients with benign hematological disease. Results More than 89. 2% MDS patients had anor-mality in 2 or 3 lineages of immuno-phenotype,among which CD7,19,13,14,33, 34.HLA-DR changed most greatly,higher than normal(P<0. 01). Myeloid series antigens were significantly increased. They showed the relular change with the progress of illness. RA-RAS increased,CD1S ,24 and lympho-linaege antigen decreased step by step. High level CD34, HLA-DR indicated poor prognosis and such MDS tend to transfer into leukemia. Conclusion Anormal immnophetotype of MDS is valuable for diagnosis.
NETL
NSTL
万方数据
维普
