摘要
目的 探讨血浆脑钠肽(BNP)和氨基末端B型尿钠肽前体(NT-proBNP)变化与心功能不全患者血管病变的关系.方法 108例心功能不全患者发病后2周内采静脉血分离血清,28例非心脏病患者作为正常对照组,用电化学发光法测定BNP和NT-proBNP.结果 对照组、心功能Ⅰ级组、Ⅱ级组、Ⅲ级组、Ⅳ级组血浆BNP水平分别是(51.34±11.27)、(155.06±39.12)、(247.05±68.34)、(513.17±127.88)(612.34±155.87).NT-proBNP(μg/L)水平分别是(25.78±14.49)、(177.86±143.65)、(299.81±166.09)、(608.17±123.14)、(979.04±176.45),组间比较差异均有统计学意义(P＜0.01).结论 血浆BNP水平升高与冠脉病变的严重程度有关,NT-proBNP可用于早期评价心脏收缩功能不全,早期评价舒张功能不全和心室壁节段运动协调性.
Abstract
Objective To explore the plasma BNP (BNP) and amino-terminal type B urinary sodium peptide precursor (NT-proBNP) change and cardiac function in patients with vascular lesions of the relationship. Methods 108 cases of patients with cardiac insufficiency 2 weeks after venous serum in separation, 28 cases of patients with heart disease as a normal control group, the chemical luminescence method to determine the BNP and NT-proBNP. Results The control group, and cardiac function Ⅰ level group, Ⅱ level group, Ⅲ level group, Ⅳ plasma BNP levels level group were (51. 34±11. 27, 155.06±39.12, 247. 05±68. 34, 513.17±127. 88 (612. 34± 155. 87). NT-proBNP (μg/L) levels were (25. 78±14. 49, 177. 86±143. 65, 299. 81 ±166. 09, 608. 17±123. 14, 979. 04± 176. 45), comparative differences between groups are statistically significant (P<0. 01). Conclusion Plasma BNP levels rise and the severity of the coronary lesions, NT-proBNP can be used to evaluate the heart to contract early function is not complete, early evaluation diastolic dysfunction and ventricular segmental wall motion coordination.
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