首页|甘氨双唑钠与紫杉醇在中晚期非小细胞肺癌放射治疗中增敏疗效比较

甘氨双唑钠与紫杉醇在中晚期非小细胞肺癌放射治疗中增敏疗效比较

扫码查看
目的 比较甘氨双唑钠(CMNa)与紫杉醇(Paclitaxel TAX)在中晚期非小细胞肺癌放射治疗中增敏疗效及不良反应.方法 首程治疗96例中晚期非小细胞肺癌患者均给予放疗,根据化疗方式分为甘氨双唑钠组、紫杉醇组及对照组.甘氨双唑钠组,甘氨双唑钠的给药方案:氯化钠溶液100 ml+CMNa1.0 g静脉滴注,每周3次;紫杉醇组,紫杉醇60 mg静脉滴注,每周1次;对照组仅行单纯放射治疗.结果 甘氨双唑钠组和紫杉醇组在有效率、放疗增敏比与对照组比较,差异有统计学意义(P<0.05).甘氨双唑钠组和紫杉醇组比较差异无统计学意义(P> 0.05),消化道、血液系统不良反应差异有统计学意义(P<0.05).结论 甘氨双唑钠与紫杉醇放射增敏疗效差异无统计学意义,但都优于单纯放疗组.甘氨双唑钠组消化道、血液系统不良反应发生率低于紫杉醇组.
Comparison of Effects of Rodiosensitization Between CMNa and Paclitaxel(TAX) in Treating Intermediate or Advanced Nonsmall Cell Lung Cancer
Objective To compare the effects of rodiosensitization between CMNa and paclitaxel(TAX) in treating intermediate or advanced non-small cell lung cancer(NSCLC). Methods total of 96 patients with intermediate or advanced stage NSCLC were divided into CMNa group.TAX group and control group by different therapy regimens. The CMNa group was treated with CMNa 1.0 g three a week plus radiotherapy. TAX group was treated with TAX 60mg once a week plus radiotherapy. The control group was treated radiotherapy only. Results There were significant differences in the effective rate and radiosensitization between the CMNa group or TAX group and the control group (P<0.05), but Without significant difference between the CMNa group and TAX group(P>0. 05). There was significant difference in the side effects of gastrointestinal tract and hematological system between the CMNa group and the TAX group (P<0.01). Conclusion There is no significant differences in the effective rate and radiosensitization between the CMN and TAX for intermediate or advanced NSCLC. , and CMNa is better than TAX in the () adverse reactions of gastrointestinal tract and hematological system.

Radiation-Sensitizing Agentstherapeutic usePaclitaxeltherapeutic useCarcinoma, Non-Small-Cell Lungdrug therapyLung Neoplasmsdrug therapy

张青、刘孟琦、高丽环

展开 >

邢台矿业集团总医院放疗科,河北邢台054000

辐射增敏药/治疗应用 紫杉酚/治疗应用 癌,非小细胞肺/药物疗法 肺肿瘤/药物疗法

2012

中国误诊学杂志
中华预防医学会 漯河市中心医院 重庆第九人民医院

中国误诊学杂志

影响因子:0.406
ISSN:1009-6647
年,卷(期):2012.12(18)
  • 3