Analysis of effect and influence factors of Thalidomide in treatment of psoriasis
Objective To evaluate the efficacy of Thalidomide in treatment of psoriasis,also to investigate the COX regression model analysis of factors influencing Thalidomide in the treatment of psoriasis. Methods 97 patients with psoriasis were separated randomly into two groups who were treated 12 weeks with Thalidomide groups (experimental group) or with MTX(methotrexate) group(control group). We compared the curative efficacy of the two groups with the Log-rank test and COX Analysis of factors influencing Thalidomide in the treatment of psoriasis. Results The median time(the patient take a turn for the better with the treatment) of the two group:the experimental group was for IS days,but the control group was for 21 days. The experimental group was significantly decreaseed compared to control group, thalidomide treated psoriasis was better than MTX. COX Analysis also demonstrated: The treatment,race,the compliance of the patients(oral drugs on time,to persist in the treatment),the expression level of IL-2 and CD4+T cell were the independent factors. Conclusion Thalidomide treated psoriasis is better than MTX, poison the side effect be less.
NETL
NSTL
万方数据
维普
