Diagnostic value of combined detection of serum tumor markers in patients with lung cancer
Objective To investigate the clinical value of combined measurement of serum CEA,CA125,NSE,CY-FRA21-1 for the diagnosis of lung cancer. Methods One hundred and sixteen patients with lung cancer confirmed histologically were studied.The levels of CEA.CA125 CYFRA21-1.NSE were assayed and compared between the lung cancer group (116 cases) and healthy control group(65 cases) by electrochemiluminesence immunoassay. Results The levels of CYFRA21-1 ,NSE,CEA,and CA125 in the lung cancer group were significantly higher than those in the control group(P<0.01). The levels of serum CEA,CA125,CYFRA 21-1 and NSE were related to types of pathology. The highest positive rates of CYFRA 21-1 for squamous cell carcinoma were 73. 21% and 63. 64％ for ade-nocarcinoma;The positivity of NSE for small cell lung cancer (SCLC) was 62.50% ;The higher levels and positivity of CEA and CA125 appeared in adenocarcinoma. Their combined detection could markedly improve the positivity for lung cancer detection (82. 76%). Conclusion CEA.CA125 .CYFRA21-1 and NSE are useful for the diagnosis of the lung cancer and histological type,especially combining detection of the four serum tumor markers. MeSH:Lung Neoplasms/metabolism; Carcinoembryonic Antigen/Blood; CA-125 Antigen/Blood; Phosphopyruvate
NETL
NSTL
万方数据
维普
