An Experimental study of Naloxone on ARDS Induced by Oleic Acid in Rats
Objective To study the therapeutic effects of Naloxone on acute respiratory distress syndrome (ARDS)in rats induced by oleic acid(OA). Methods 30 healthy Wistar rats were randomly divided into three groups: Control group, ARDS group, Naloxone-treated group. ARDS model was induced by UA (0.1 ml/mg) injecting via femoral vein. SOD and MDA level in lung tissue,the wet to dry ratio(W/D) of left lung tissue were measured, and pulmonary pathological changes were compared among the three groups. Results Compared with Control group, the wet to dry ratio( W/D) of left lung tissue,MDA in lung tissue in ARDS group showed significant increase. At the same time, SOD in lung tissue decreased greatly, and more typical pathological changes in lung tissue treated by OA. The changes in Naloxone-treated group were better than in ARDS group. Conclusions Naloxone can inhibit the increase of MDA and improve SOD activity, Naloxone has therapeutic effects on ARDS rats induced by OA.
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