Study on a new oral biological care solution of compound lysostaphin
Objective To study a new compound lysostaphin oral biological care solution and its related properties.Methods Using formula screening and suspension quantitative sterilization test methods,the related properties of a new compound lysostaphin were detected and evaluated.Results The main bactericidal component of the new compound lysostaphin oral biological care solution was recombinant lysostaphin,and its content ranged from 1 000 mg/L to 3 000 mg/L.The stock solution of this care solution was used to act on Staphylococcus aureus,Escherichia coli,and Candida albicans in suspension for 5 min respectively,and the killing rates were all≥90％.The irritation index of the care solution to the oral mucosa of golden hamsters was 0,and the sensitization rate to the skin of guinea pig was 0％.Conclusion The new compound lysostaphin oral biological care solution has good stability and ability of film forming,which has a killing rate of more than 90％against test bacteria.It non-irritating to the intact skin and mucous membranes of experimental animals.
compound lysostaphinlysozymeoral biological care solutionbactericidal effect
NETL
NSTL
万方数据
维普
