Disinfection effect and safety of a polyhexamethylene biguanide for fruit and vegetable
Objective To investigate the efficacy and safety of polyhexamethylene biguanide(PHMB)as a fruit and vegetable disinfectant.Methods According to the technical requirements of hygienic safety evaluation of disinfected products,the physical and chemical properties of PHMB were determined,such as pH value,heavy metal content,PHMB content and stability.The disinfection effects were evaluated by tests of the identification of neutralizers,microbial killing effect,and on-site test of object surface disinfection.The toxicological safety were evaluated by tests of acute oral toxicity,mutagenicity,and one-time intact skin irritation.Results At 25℃,the pH value of the disinfectant was 7.08.The content of As was＜0.01 mg/kg,Hg was＜0.002 mg/kg,Pb was＜1.5 mg/kg.The content of PHMB was 0.497 g/kg.After being stored at 37℃for 3 months,the content of PHMB decreased to 0.492 g/kg.Decrease rate was 1.27%(w/w).Incubated for 5 min,the killing logarithms(KL)of E.coli in suspension were all＞5.00,and the average KL for natural bacteria on cucumber surface were＞1.00.The acute oral toxicity of the disinfectant was actually non-toxic,and the micronucleus test of mouse bone marrow polychromatic red blood cells had no micronucleus effect,and a complete skin irritation test was non-irritating.Conclusion The disinfectant has good disinfection effect,stability and safety for fruit and vegetable disinfection.
polyhexamethylene biguanidefruit and vegetable disinfectantdisinfection effecttoxicological safety
万方数据
维普
