Sensitivity of drug-resistant Klebsiella pneumoniae carrying different carbapenemase-type genes to the commonly used anti-CRKP drugs
Objective To investigate the distribution of carbapenemase-type genes in CRKP strains in Ningbo,and to investigate the sensitivity of CRKPs carrying different carbapenemase-type genes to the commonly used anti-CRKP drugs.Methods A total of 150 CRKP strains isolated from clinical non-duplication in hospitals in Ningbo from January 2019 to December 2021 were selected,and the carbapenemase genes were detected by PCR.The broth dilution method was used to detect the sensitivity of the commonly used anti-CRKP drugs tigecycline,polymyxin B and ceftazidime/avibactam to the isolation of CRKP.The K-B method was used to detect the sensitivity of CRKP to 8 kinds of combination drugs used in reports.Results The CRKP strains in this region mainly carried KPC-2 resistance genes,followed by NDM-1 resistance genes,and had high susceptibility rates to tigecycline and polymyxin B.Ceftazidime/avibactam had effect on CRKP carrying class A enzyme genes,but had weak effect on CRKP carrying class B and D enzyme genes.Fosfomycin,amikacin,and chloramphenicol had a large inhibition zone diameter and could be used as combination drugs for the treatment of CRKP infection.Aztreonam and amikacin could be used to treat CRKP infection carrying class B enzyme genes.Conclusion Antimicrobial drugs have different effect on strains carrying different enzyme types and genes.
CRKPcarbapenemase typetigecyclineceftazidime/avibactampolymyxin B
万方数据
维普
