Study on antibacterial activity and safety of a compound biological disinfectant
Objective To observe the antibacterial activity and safety of a compound biological disinfectant containing antimicrobial peptide(AMP)and polyhexamethylene biguanide(PHMB)as main components.Methods Suspension quantitative bactericidal test and animal test methods were used to observe the antibacterial activity and safety of the compound biological disinfectant.Results When incubated with the compound biological disinfectant for 1 min,the average killing log value of the disinfectant for Staphylococcus aureus,Escherichia coil and Pseudomonas aeruginosa were>5.0,and that were>4.0 for Candida albicans.The LD50 value of the disinfectant for mice was>5 000 mg/(kg·bw),which belonged to a practical non-toxic level.The original solution of the disinfectant had no irritating effect to the intact skin and mucous membranes of rabbits.Conclusion The compound biological disinfectant has good antibacterial effect and biological safety.
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