Pathogen distribution and clinical features of central line associated blood stream infection in very low birth weight infants
Objective To investigate the clinical characteristics and pathogen distribution of central line associated blood stream infection(CLABSI)in very low birth weight infants.Methods Through a retrospective survey method,the clinical medical records of CLABSI infected infants with a birth weight<1 500 g in the neonatal intensive care unit(NICU)of a hospital were analyzed.Results A total of 134 CLABSI cases were included in this study.Mean gestational age was<30 weeks and mean birth weight was 1 200 g.A total of 134 strains of 23 pathogens were identified from microbiological specimens of infants with CLABSI infection.Among them,Gram negative bacteria,Gram positive bacteria,and fungi accounted for 60.45%,23.38%,and 15.67%,respectively.The constituent ratio of Klebsiella pneumoniae,Candida mirabilis,and Clostridium perfringens were the top three. The rates of complications and treatment failure of CLABSI were high, including necrotising enterocolitis (23.46％), septic shock(18.52％), and treatment failure (14.81％). Conclusion The main pathogens of CLABSI in very low birth weight infants are mainly Gram-negative bacteria.The incidence of complications in CLABSI is high, and the prognosis is poor.
very low birth weight infantscentral line associated blood stream infectionpathogenic bacteria
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