Epidemic characteristics of carbapenem resistant Klebsiella pneumoniae infection in a certain hospital from 2012 to 2023
Objective To investigate and analyze the detection rate of carbapenem-resistant Klebsiella pneumoniae(CRKP)in clinical specimens of a hospital and its related clinical characteristics,so as to provide a basis for rational medicine use and prevention and control of CRKP nosocomial infection.Methods A retrospective investigation method was used to collect the data of Klebsiella pneumoniae isolated from clinical specimens of patients in clinical departments from 2012 to 2023.The CRKP detection was compared from different sources,departments and types of patients,and the changes of pathogen resistance were analyzed.Results The detection rate of CRKP in the non-bloodstream infection group was higher than that in the bloodstream infection group(11.2％vs 7.9％;x2=11.534,P=0.001).The detection rates of CRKP in blood,sputum,bronchoalveolar lavage fluid,urine,and cerebrospinal fluid showed an overall rising trend over time(P＜0.05).The detection rate of CRKP in ICU was higher than that in non-ICU(16.1％vs 8.9％;x2=100.564,P＜0.001).The detection rates of CRKP in the adult group and the elderly group showed an overall upward trend(Z=10.105 and 12.107,P＜0.05),while the neonatal group showed a downward trend(Z=-2.099,P=0.036).CRKP exhibited high resistance to ceftazidime,ceftriaxone,cefazolin,ertapenem,and ampicillin/sulbactam,with drug resistance rates exceeding 95％.Conclusion Hospitals should strengthen the effective monitoring of important types of specimens,key wards and special groups,and standardize the rational use of antibiotics.
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