中国消毒学杂志2024,Vol.41Issue(7) :485-488.DOI:10.11726/j.issn.1001-7658.2024.07.002

气相色谱-质谱联用法测定消毒湿巾中5种氯型季铵盐含量

Determination of the contents of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes using gas chromatography-mass spectrometry

刘波 霍宗利 张婧婧
中国消毒学杂志2024,Vol.41Issue(7) :485-488.DOI:10.11726/j.issn.1001-7658.2024.07.002

气相色谱-质谱联用法测定消毒湿巾中5种氯型季铵盐含量

Determination of the contents of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes using gas chromatography-mass spectrometry

刘波 1霍宗利 2张婧婧2
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作者信息

  • 1. 泰州市疾病预防控制中心,江苏泰州 225300
  • 2. 江苏省疾病预防控制中心
  • 折叠

摘要

目的 建立气相色谱-质谱联用法同时检测消毒湿巾中5种氯型季铵盐含量的方法.方法 采用气相色谱-质谱联用测定法,对消毒湿巾中 5 种氯型季铵盐含量进行检测,确定检测方法的实用性.结果 在建立优化检测条件下,对消毒湿巾中氯型季铵盐在5~60 µg/mL的浓度范围内线性关系良好(r>0.999 3),方法检出限均为1.1~1.6 µg/mL,平均回收率在 86.2%~106.6%,RSD在 1.4%~6.7%.结论 本研究建立的气相色谱-质谱联用法具有操作简便、快速、重现性好等优点,可同时对消毒湿巾中5种氯型季铵盐含量进行测定.

Abstract

Objective To establish a method for simultaneous detection of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes using gas chromatography-mass spectrometry.Methods Gas chromatography-mass spectrometry was used to detect the contents of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes to determine the practicability of the detection method.Results Under the optimized detection condition,the linear relationship between chlorine-type quaternary ammonium salts in disinfectant wipes was good in the concentration range of 5 to 60 µg/mL(r>0.999 3),and the method detection limits were all 1.1 to 1.6 µg/mL,the average recovery rate was between 86.2%and 106.6%,and the RSD was between 1.4%and 6.7%.Conclusion The gas chromatography-mass spectrometry method established in this study has the advantages of simple operation,rapidity,and good reproducibility.It can simultaneously determine the contents of 5 kinds of chlorine-type quaternary ammonium salt in disinfectant wipes.

关键词

消毒湿巾/消毒剂/氯型季铵盐/气相色谱-质谱法

Key words

disinfectant wipes/disinfectants/chlorine-type quaternary ammonium salts/gas chromatography-mass spectrometry

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基金项目

江苏省青年医学人才项目(QNRC2016543)

江苏省333高层次人才培养工程([2022]3-7-023)

出版年

2024
中国消毒学杂志
军事医学科学院疾病预防控制所,中华预防医学会

中国消毒学杂志

CSTPCD
影响因子:0.754
ISSN:1001-7658
参考文献量19
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