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一种多肽生物消毒剂消毒相关性能研究

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目的 研究一种多肽新型生物消毒剂杀菌效果及安全性.方法 采用悬液定量杀菌试验和动物毒性试验方法,对某多肽新型生物消毒剂的消毒相关性能进行观察.结果 用浓度为5 500 mg/L的该多肽生物消毒剂溶液作用10 min,对悬液内的大肠埃希菌、金黄色葡萄球菌和铜绿假单胞菌的杀灭对数值均>5.0,对白念珠菌的杀灭对数值>4.0.该消毒剂最高使用浓度5倍溶液对大鼠和小鼠急性经口毒性LD50值均>5 000 mg/(kg·bw),一次完整皮肤刺激试验为无刺激性;未见皮肤变态反应;V79细胞基因突变试验结果为阴性;小鼠精母细胞染色体畸变试验结果为阴性;小鼠骨髓嗜多染红细胞微核试验结果为阴性;致畸指数<10.结论 该多肽生物消毒剂具有良好的杀菌效果,属于实际无毒级物质,无刺激性和致突变性.
Study on the disinfection-related properties of a polypeptide biological disinfectant
Objective To study the bactericidal effect and safety of a new biological disinfectant.Methods Suspension quantitative bactericidal test and animal test methods were used to observe the disinfection-related properties of a new polypeptide biological disinfectant.Results When the polypeptide biological disinfectant solution with a concentration of 5 500 mg/L was used for 10 min,the killing log values of Escherichia coli,Staphylococcus aureus,and Pseudomonas aeruginosa in suspension were all>5.0,and the killing log values of Candida albicans,was>4.0.The acute oral toxicity LD50 values of this disinfectant solution to rats and mice at 5 times the highest concentration were both>5 000 mg/(kg·bw).An intact skin irritation test was non-irritating;and no skin allergies were seen.The V79 cell gene mutation test results were negative;the mouse spermatocyte chromosome aberration test results were negative;the mouse bone marrow polychromatic erythrocyte micronucleus test results were negative;the teratogenicity index was<10.Conclusion This polypeptide biological disinfectant has good bactericidal effect,and is a practical non-toxic substance,and has no irritation or mutagenicity.

biological disinfectantpolypeptidebactericidal effectsafety

凌建群、石君连、余海、林青萍、葛展霞、李思嘉

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南宁吉锐生物医药有限责任公司,广西南宁 535000

生物消毒剂 多肽 杀菌效果 安全性

广西重点研发计划项目南宁市创新创业领军人才邕江计划

桂科AB202970152020012

2024

中国消毒学杂志
军事医学科学院疾病预防控制所,中华预防医学会

中国消毒学杂志

CSTPCD
影响因子:0.754
ISSN:1001-7658
年,卷(期):2024.41(7)
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