Bacteriostasis potency of various antimicrobial agents against Burkholderia cepacia
Objective To observe the bacteriostasis potency of 13 individual antimicrobial agents and 6 compound liquids against Burkholderia cepacia.Methods The tube suspension method was used to monitor the survival of Burkholderia cepacia in various individual antimicrobial agents and compound liquids.Results Among the 13 commonly used individidual antimicrobial agents,a 2.0%solution of 1,2-hexanediol and a 0.08%dodecyl dimethyl benzyl ammonium chloride incubating for 0.5 h,0.15%methylparaben inccubating for 24 h,and 0.10%ethylparaben incubating for 1 h,the killing log value for Burkholderia cepacia decreased by≥5.0,and the killing log values of other individual components were≤3.0 after incubationg for 28 d.The number of bacteria in the test system of 0.15%ethylparaben,0.08%and 0.12%cetylpyridine chloride could still increase when the number of bacteria in the system<10 cfu/mL.The bacteriostasis efficacy of 0.05%caprylhydroxamic acid+0.15%p-hydroxyacetophenone and 0.13%dodecyl dimethyl benzyl ammonium chloride+0.06%cetylpyridine chloride did not meet the ISO 11930"Evaluation of the antimicrobial protection of a cosmetic product"requirements,and the bacteriostasis efficacy of the other four compounds met the requirements.Conclusion The bacteriostasis potency of individual antimicrobial agents against Burkholderia cepacia can be enhanced by specific compounding.
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