摘要
目的 研究赤藓红介导的光动力效应对甲型流感病毒的灭活效果.方法 采用细胞培养法,对赤藓红介导的光动力效应灭活甲型H1N1、H3N2 和H9N2 流感病毒的效果进行观察.结果 用 50 μmol/L的赤藓红经蓝色LED光照 5 min,对甲型H1N1、H3N2 和H9N2 流感病毒的平均灭活对数值依次为 5.44、2.56 和 4.89 TCID50.赤藓红介导的光动力效应对不同材质物体表面甲型H1N1、H3N2 和H9N2 流感病毒灭活率依次为≥99.99%、≥99.72%和≥99.97%.结论 赤藓红介导的光动力效应对甲型H1N1、H3N2 和H9N2 流感病毒具有良好的灭活效果.
Abstract
Objective To investigate the effect of erythrosine-mediated photodynamic inactivation(PDI)on influenza A virus.Methods Cell culture method was used to observe the effect of erythrosine-mediated PDI on influenza A H1N1,H3N2,and H9N2 viruses.Results 50 μmol/L erythrosine was illuminated with blue LED light for 5 min,and the average inactivation logarithmic values of influenza A H1N1,H3N2,and H9N2 were 5.44,2.56,and 4.89 TCID50,respectively.The inactivation rates of erythrosine-mediated PDI on influenza A H1N1,H3N2,and H9N2 viruses on surfaces of different materials were≥99.99%,≥99.72%,and≥99.97%,respectively.Conclusion The erythrosine-mediated PDI has a good inactivation effect on influenza A H1N1,H3N2,and H9N2 viruses.
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