Distribution characteristics and resistance rate changes of pathogens in pediatric surgery at a children's hospital from 2019 to 2023
Objective To analyze the distribution characteristics of pathogens and the changes of drug resistance rate,and to provide references for rational clinical use of drug and treatment.Methods Non-repetitive strains of bacterial culture were collected in department of pediatric surgery from 2019 to 2023 and analyzed retrospectively.Results A total of 2 188 pathogens were detected,including 1 527 gram-negative bacteria(69.78%)and 609 Gram-positive bacteria(27.83%).The top four pathogens were Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus and Klebsiella pneumoniae.Peritoneal and soft tissue pus accounted for 79.52%and 5.90%respectively among all specimens.The resistance rate of E.coli to ceftriaxone showed an increasing trend(P<0.05).The resistance rate of S.aureus to penicillin ranged from 81.8%to 100%,that of erythromycin and clindamycin fluctuated between 51.0%and 70.8%.Conclusion Gram negative bacilli were the main strains isolated from pediatric surgery in our hospital,which are mainly detected in abdominal pus and urine samples,while S.aureus is mainly detected in soft tissue pus,orthopedic pus,and venous blood.The drug resistance of pathogens should be monitored and analyzed regularly,and the indication of antibiotic application should be strictly enforced to prevent and slow down the generation of drug-resistant bacteria.
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