Analysis of multidrug-resistant organisms surveillance results in a level-A terfiary hospital from 2020 to 2022
Objective To analyze the detection of multidrug-resistant bacteria(MDROs),the current status of infection and the changes of drug resistance in a tertiary hospital for three consecutive years,so as to provide a basis for the prevention and control of MDROs infection and the selection of antimicrobial drugs.Methods A retrospective survey was conducted to analyze the surveillance of 1 456 MDROs detected in hospital inpatients from January 2020 to December 2022.Results A total of 19 770 bacterial culture specimens were sent for testing,and 5 255 positive strains were detected,of which 1 456 strains were MDROs,with a detection rate of 27.71%and an infection incidence rate of 0.28%.The detection rates of carbapenem-resistant Enterobacteriaceae(CRE),carbapenem-resistant Pseudomonas aeruginosa(CRPA)and carbapenem-resistant Acinetobacter baumannii(CRAB)showed an increasing trend(P<0.05).The incidences of CRE,CRPA and methicillin-resistant Staphylococcus aureus(MRSA)infection showed an increasing trend(P<0.05).The resistance of ESBLs-producing E.coli to cefepime and aztreonam showed an upward trend(P<0.05).The resistance of ESBLs-producing Klebsiella pneumoniae to piperacillin,tazobactam,aztreonam,gentamicin,levofloxacin,ciprofloxacin and nitrofurantoin showed an increasing trend(P<0.05).The resistance of CRAB to cefepime showed an upward trend(P=0.043).The resistance of CRPA to meropenem,tobramycin,gentamicin,levofloxacin and ciprofloxacin showed an upward trend(P<0.05).The resistance of MRSA to ceftriaxone showed an upward trend(P=0.018).Conclusion MDROs infection is on rise,and drug resistance is becoming more and more serious,so antimicrobial drugs should be used rationally according to the drug sensitivity results.
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