222nm紫外线对实验动物皮肤及眼刺激性的实验研究
Experimental study on the irritation of 222 nm ultraviolet radiation on the skin and eyes of experimental animals
李锦 1许春 1陈睿 2巩爱华 2苏裕心2
作者信息
- 1. 北京首量科技股份有限公司,北京 101111
- 2. 中关村国际医药检验认证科技有限公司
- 折叠
摘要
目的 观察222 nm紫外线对小鼠皮肤和日本大耳白兔眼的刺激性.方法 按照2002年版《消毒技术规范》中规定的皮肤刺激性试验和眼刺激性试验方法,观察222 nm紫外线对KM小鼠皮肤和日本大耳白兔眼的刺激性,并与254 nm紫外线的作用效果进行平行比较.结果 在大剂量单次照射试验或小剂量15 d连续照射试验中,254 nm紫外线引起小鼠皮肤刺激性反应,表现为表皮增厚和胶原纤维含量下降;眼刺激性反应表现为角膜浑浊、虹膜边界模糊和结膜充血.相同试验条件下,222 nm紫外线辐照未引起实验动物皮肤和眼刺激性反应.结论 222 nm紫外线比254 nm紫外线有更高的安全性.
Abstract
Objective To observe the irritation of 222 nm ultraviolet radiation on the skin of mouse and eyes of Japanese white rabbit.Methods According to the skin irritation test and eye irritation test methods specified in document"Technical Standard for Disinfection"(2002 edition),the iritation of 222 nm ultraviolet radiation on KM mouse skin and Japanese white rabbit eyes was observed and compared with the effect of 254 nm ultraviolet radiation in parallel.Results In high-dose single irradiation experiments or low-dose 15 d continuous irradiation experiments,254 nm ultraviolet radiation caused skin irritation reactions in mice,manifested as epidermal thickening and decreased collagen fiber content.The irritating reaction of rabbit eyes was manifested as corneal opacity,blurred iris boundaries,and conjunctival congestion.Under the same experimental conditions,222 nm ultraviolet irradiation did not cause skin and eye irritation reactions in experimental animals.Conclusion 222 nm UV has higher safety than 254 nm UV.
关键词
222nm紫外线/皮肤刺激/眼刺激/动物实验Key words
222 nm ultraviolet radiation/skin irritation/eye irritation/animal experiments引用本文复制引用
出版年
2024
NETL
NSTL
万方数据