Experimental study on the irritation of 222 nm ultraviolet radiation on the skin and eyes of experimental animals
Objective To observe the irritation of 222 nm ultraviolet radiation on the skin of mouse and eyes of Japanese white rabbit.Methods According to the skin irritation test and eye irritation test methods specified in document"Technical Standard for Disinfection"(2002 edition),the iritation of 222 nm ultraviolet radiation on KM mouse skin and Japanese white rabbit eyes was observed and compared with the effect of 254 nm ultraviolet radiation in parallel.Results In high-dose single irradiation experiments or low-dose 15 d continuous irradiation experiments,254 nm ultraviolet radiation caused skin irritation reactions in mice,manifested as epidermal thickening and decreased collagen fiber content.The irritating reaction of rabbit eyes was manifested as corneal opacity,blurred iris boundaries,and conjunctival congestion.Under the same experimental conditions,222 nm ultraviolet irradiation did not cause skin and eye irritation reactions in experimental animals.Conclusion 222 nm UV has higher safety than 254 nm UV.
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