Distribution and drug resistance analysis of bacteria from lower respiratory tract in hospitalized patients of a grade 3A hospital from 2021 to 2023
Objective To investigate the distribution and antimicrobial resistance of bacteria isolated from lower respiratory tract in a grade 3A hospital,so as to provide a reference for the rational use of antibiotics.Methods Retrospective survey was conducted to monitor and analyze the bacteriological examination and drug sensitivity test results of submitted specimens of hospitalized patients with lower respiratory tract in the hospital from 2021 to 2023.Results A total of 6 417 strains of bacteria were detected for 3 years,mainly gram-negative bacteria(90.7%).The top five pathogens were Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumannii,Staphylococcus aureus and Escherichia coli,accounting for 31.0%,17.4%,14.0%,8.2%and 8.0%,respectively.The detection rate of methicillin-resistant Staphylococcus aureus was 41.2%.No S.aureus strains were found resistant to vancomycin or linezolid.The resistance rates of E.coli and E.cloacae to carbapenem antibiotics were no more than 11%.The resistance rates of A.baumannii to imipenem was more than 50%.Conclusion The bacteria isolated from lower respiratory tract specimens in this hospital were predominantly gram-negative,notably carbapenemase-resistant Enterobacterales and carbapenem-resistant Acinetobacter baumannii,highlighting the need for enhanced prevention and control measures to effectively curb or mitigate the risk of nosocomial transmission.