Analysis of pathogen distribution and drug resistance of respiratory tract infection in winter for pediatric inpatients in a hospital from 2018 to 2023
Objective To understand the distribution characteristics of pathogens and drug resistance changes of winter respiratory tract infections of pediatric inpatients in a hospital from 2018 to 2023,so as to provide a reference for clinical diagnosis and treatment and nosocomial infection control.Methods A retrospective survey method was used to collect and analyze the clinical data and bacteriological test results of hospitalized patients with pediatric respiratory tract infections in the first quarter of 6 consecutive years.Results 2 599 strains of the pathogen were isolated from the respiratory tract of 5 751 patients,and the Gram-negative bacteria were Haemophilus influenzae(38.72%),Escherichia coli(24.34%)and Klebsiella pneumoniae(10.19%).H.influenzae showed resistance to ampicillin,cotrimoxazole,cephalosporin,and azithromycin by up to 89.3%,and E.coli and K.pneumoniae to cotrimoxazole,gentamicin,and cephalosporin by up to 77.0%.Gram-positive bacteria were mainly Staphylococcus aureus(62.52%)and Streptococcus pneumoniae(30.72%),of which methicillin-resistant S.aureus accounted for 64.4%.S.pneumoniae showed resistance to erythromycin,cotrimoxazole,and clindamycin by up to 100%.Fungi mainly was C.albicans,accounting for 78.53%.Conclusion The pathogens of winter respiratory tract infections in the pediatric department of this hospital are highly resistant to a variety of antimicrobial drugs.While the rational use of antibacterial drugs,pediatric inpatient environment disinfection should be targeted.