Study on Anti-Dandruff Protocol Alternative to Zinc Pyrithione in Shampoo
With the ban on zinc pyrithione in the EU,the quest for an alternative dandruff agent becomes imperative.This study utilized Malassezia furfur and Malassezia restricta as indicator bacteria,employing self-established in vitro methods to screen and evaluate potential dandruff agents.These methods included assessing bacteriostatic rate,bacteriostatic ring formation,and minimum inhibitory concentration.By comparing the dandruff efficacy of zinc pyrithione,ketoconazole ethanolamine,climbazole,and salicylic acid,a dandruff treatment alternative was selected,which includes 0.25%ketoconazole ethanolamine salt and 0.4%climbazole to replace zinc pyrithione.The dandruff shampoo formulated with this dandruff treatment alternative was compared with a shampoo containing zinc pyrithione.It was found that after continuous use for 14 and 28 days,there was a significant reduction in dandruff with both shampoos,indicating their efficacy in reducing dandruff.Results from third-party human dandruff efficacy testing of this dandruff treatment alternative showed a significant decrease in dandruff scores after 14 and 28 days of use.This finding indicates its effective dandruff reduction properties.Through heat stability testing,the shampoo system replacing zinc pyrithione demonstrated significantly better stability compared to the shampoo containing zinc pyrithione.
replacement of zinc pyrithioniumMalasseziadandruff removal test
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