Preparation and Efficacy Study of a Traditional Chinese Medicine Antibacterial and Antipruritic Spray
Objective:A Chinese medicinal antibacterial and antipruritic spray was formulated and evaluated for its antibacterial efficacy and antipruritic effects through antibacterial testing and the establishment of a mouse itch model.Methods:The bacteriostatic effect of bacteriostatic and antipruritic spray was tested using the method described in Appendix C of GB 15979-2002 Hygienic Standard for Disposable Hygienic Products;A mouse itching model was established by continuously administering 2,4-dinitrochlorobenzene(DNCB)acetone solution for 7 days.The low-dose group,medium dose group,and high-dose group were administered continuously to investigate their anti-itching effect.Result:The medium dose and high dose groups had strong antibacterial properties against Staphylococcus aureus,Escherichia coli,and Candida albicans;After administering the antibacterial and antipruritic spray to the mouse itching model,the skin swelling degree and skin allergy score of the low-dose,middle-dose,and high-dose groups decreased significantly compared to those of the normal and positive control groups.Conclusion:The medium and high dose groups of the antibacterial and antipruritic spray exhibited strong antibacterial activity against Staphylococcus aureus,Escherichia coli,and Candida albicans.Additionally,the low,middle,and high doses of the antibacterial and antipruritic spray demonstrated certain antipruritic effects in the mouse itch model.
NETL
NSTL
万方数据
