Clinical Application and Drug Interaction Analysis of Nirmatrelvir/Ritonavir Tablets in Children
OBJECTIVE To analyze the drug-drug interaction during the use and treatment of nirmatrelvir/ritonavir tablets in children,and to provide reference for rational drug use in clinical practice.METHODS All hospitalized pediatric patients with using nirmatrelvir/ritonavir tablets from December 23,2022 to February 8,2023 in Children's Hospital,Zhejiang University School of Medicine were collected.The use of nirmatrelvir/ritonavir was analyzed,and the combination drugs were classified.The potential clinical drug-drug interactions of nirmatrelvir/ritonavir were analyzed through micromedex drug interaction database and the severity was graded.RESULTS A total of 48 patients using nirmatrelvir/ritonavir tablets were collected,with a median age of 6.71 years old(87 d-17.75 years old).The usage departments were mainly in the departments of hematology,ICU,infectious disease,and general internal medicine,and the main underlying disease being tumors.The median fever-reducing time after medication was 3 d.Many drugs were combined during medication period.A total of 15 potential drug-drug interaction drugs of nirmatrelvir/ritonavir tablets were collected,and potential drug interaction with antifungals should be considered.CONCLUSION The department with more usage of nirmatrelvir/ritonavir tablets in children is hematology,and the main underlying disease is tumors.When nirmatrelvir/ritonavir tablets are used in combination with potential drug-drug interaction drugs,attention should be paid to monitoring the efficacy and adverse reactions.
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万方数据
维普
