Study on Content Determination and Immunomodulatory and Cardioprotective Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder Tablet
OBJECTIVE To investigate the potential therapeutic effect of the sporoderm-removed Ganoderma lucidum spore tablet"Xianzhi No.3"from the perspective of immunomodulation and cardioprotection.METHODS Chemical components of the sporoderm-removed Ganoderma lucidum spore tablet"Xianzhi No.3"were analyzed by UPLC-Q-TOF-MS and colorimetric methods.Examined tablet's effects on zebrafish models of macrophage reduction,heart failure,H2O2-induced oxidative stress in myocardial and endothelial cells,and a microglial inflammation model induced by lipopolysaccharide.Immune regulation and cardioprotective effects were evaluated through multiple indicators,including macrophage formation and phagocytosis abilities,anti-neuroinflammation ability,cardiac systolic and diastolic functions,and anti-oxidative stress injury ability in myocardial and endothelial cells.RESULTS The sporoderm-removed Ganoderma lucidum spore tablet"Xianzhi No.3"improved macrophage formation and phagocytosis,cardiac systolic and diastolic functions,reduced neuroinflammation,and alleviated oxidative stress in myocardial and endothelial cells,resulting in immunomodulatory and cardioprotective effects.CONCLUSION The sporoderm-removed Ganoderma lucidum spore tablet"Xianzhi No.3"maybe a potential therapeutic agent for regulating the immune system and protecting cardiac function.
万方数据
维普
