OBJECTIVE To clarify the weight index and optimize the technology of compound Mingmu Yijing pills.METHODS Water content,dissolution time limit and bolus-forming pass rate were included as evaluation indexes.The analytic hierarchy process(AHP)and the criterion importance through inter-criteria correlation(CRITIC)method based on the objectivity of indicators were adopted,AHP-CRITIC mixed weighting method.In this way,the relative coefficients of each index were calculated for weight distribution and comprehensive score,and the molding process was optimized and verified by Box-Behnken response surface test.RESULTS Compared with the single weighting method,the AHP-CRITIC mixed weighting method was more reasonable and stable.This method finally optimized the forming process conditions of Mingmu Yijing pills as follows:adding water amount of 0.8 times,the damp mass infiltration for 0.5 h,drying temperature of 60 ℃,drying time of 8 h.The mean comprehensive score of validation experiment was 88.21,RSD was 0.29％.CONCLUSION AHP-CRITIC method scientifically determines the weight of multiple indicators,and the verification test confirms that the optimized molding process is stable and feasible,which can be used in practical large-scale production.
维普
万方数据