摘要
夏枯草作为一味临床常用中药,具有清肝泻火、明目、散结消肿的功效,对甲状腺癌、乳腺癌、肝癌等多种肿瘤表现出较强的抗肿瘤作用.夏枯草提取物及其有效成分可通过多种途径发挥抗肿瘤作用,其主要途径包括诱导细胞凋亡、抑制细胞侵袭及转移、抑制细胞增殖、诱导自噬、抗肿瘤血管生成、逆转肿瘤多药耐药性和调节免疫功能等,并通过调控miRNA 和 Wnt/β-catenin、PI3/Akt、AMPK/mTOR/ULK1、RANKL/RANK/OPG 等信号通路发挥作用.本文对夏枯草提取物抗肿瘤的作用机制等进行总结,以期为其进一步的研究和应用提供参考.
Abstract
As a common clinical Chinese medicine,Prunellae Spica has the effects of clearing liver-fire,improving eyesight,resolving massesand detumescence,and has strong anti-tumor effects against thyroid cancer,breast cancer,liver cancer and other cancers.Extracts of Prunellae Spica and its active components can play an anti-tumor role in a variety of ways,including cell apoptosis,inhibiting cell invasion and metastasis,inhibiting cell proliferation,inducing autophagy,anti tumor angiogenesis,reversing tumor multidrug resistance and regulating immune function,by regulating miRNA and Wnt/β-catenin,PI3/AKT,AMPK/mTOR/ULK1,RANKL/RANK/OPG and other signal pathways.In this paper,the anti-tumor mechanism of Prunellae Spica extract was reviewed,in order to provide reference for further research and application.
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