Research Progress in Anti-tumor Mechanisms of Prunellae Spica and Its Active Components
As a common clinical Chinese medicine,Prunellae Spica has the effects of clearing liver-fire,improving eyesight,resolving massesand detumescence,and has strong anti-tumor effects against thyroid cancer,breast cancer,liver cancer and other cancers.Extracts of Prunellae Spica and its active components can play an anti-tumor role in a variety of ways,including cell apoptosis,inhibiting cell invasion and metastasis,inhibiting cell proliferation,inducing autophagy,anti tumor angiogenesis,reversing tumor multidrug resistance and regulating immune function,by regulating miRNA and Wnt/β-catenin,PI3/AKT,AMPK/mTOR/ULK1,RANKL/RANK/OPG and other signal pathways.In this paper,the anti-tumor mechanism of Prunellae Spica extract was reviewed,in order to provide reference for further research and application.
Prunellae Spicaanti-tumorextractactive ingredientsmechanism of actionclinical application
万方数据
维普
