A Case Report and Literature Review of A Child with Refractory Anti-N-methyl-D-aspartate Receptor Encephalitis Treated with Tocilizumab
OBJECTIVE To explore the safety and effiicacy of tocilizumab in the treatment of refractory anti-N-methyl-D-aspartate receptor encephalitis in children,and to provide reference for the treatment of this disease.METHODS The clinical manifestations,diagnosis and treatment,safety and efficacy of tocilizumab in a case of refractory anti-NMDAR encephalitis in Children's Hospital,Zhejiang University School of Medicine were analyzed retrospectively,and the relevant literature was reviewed.RESULTS The clinical symptoms of the patient were not improved after 2 doses of methylprednisolone,immunoglobulin and 6 doses of rituximab.After 6 doses of tocilizumab,the modified Rankin scale(mRS)score was improved without adverse reactions.CONCLUSION Tocilizumab,as a escalation second-line immunotherapy,is effective and well tolerated in the treatment of refractory anti-NMDAR encephalitis.It is one of the potential therapeutic means.
万方数据
维普
