抗体与抗原结合的靶向递送是一种精准的递药方式，由于其高特异性和亲和力被视为理想的靶向递药方式之一，这为成功解决抗肿瘤治疗中化疗药物选择性差的问题开辟了新的道路。当前，利用单克隆抗体与靶抗原结合的抗体偶联药物(antibody drug conjugates，ADCs)研究成为分子靶向治疗的研究热点，本文就ADCs靶向递送的作用机制、靶向策略和靶向递送进展进行综述，以期为临床开发新的ADCs提供参考。
Advances in the Targeted Delivery of Antibody Drug Conjugates
Targeted delivery of antibody bound to antigen is a precise drug delivery mode.It is regarded as one of the ideal targeted drug delivery modes due to its high specificity and affinity,which opens up a new way to successfully solve the problem of poor selectivity of chemotherapy drugs in antitumor therapy.Currently,the research on antibody drug conjugates(ADCs)that bind monoclonal antibodies to target antigens has become a research hotspot of molecular targeted therapy.This paper reviews the mechanism of action,targeting strategies and progress in the targeted delivery of ADCs,in order to provide reference for the clinical development of new ADCs.
targeted deliveryantibody drug conjugatesmalignant tumortreatmentprogress
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