纳豆激酶递送系统研究进展
Research Progress of Nattokinase Delivery System
刘帅 1荣晓辉 1张书锋 1屈磊 1刘芳 2井娟1
作者信息
- 1. 陆军军医大学士官学校医技保障系,石家庄 050081
- 2. 解放军总医院京南医疗区,北京 100036
- 折叠
摘要
血栓栓塞性疾病严重影响着人们的身心健康,甚至危害生命.纳豆激酶(nattokinase,NK)是一种碱性丝氨酸蛋白酶,具有溶栓活性强、不良反应小等优点.但NK经口服给药,会被胃酸和胃蛋白酶降解,失去溶栓活性.采用制剂技术可以形成保护层,提高NK的生物利用度.本文简要介绍了 NK的药理性质,讨论了 NK不同剂型的特性,对NK制剂的发展进行了展望,以期促进其研究和应用.
Abstract
Thromboembolic disease seriously affects people's health,and even endangers life.Nattokinase(NK)is an alkaline serine protease with strong thrombolytic activity and low toxicity.However,when NK passes through the stomach,it is degraded by gastric acid and pepsin,and subsequently loses its thrombolytic activity.The application of preparation technology can form a protective layer and improve the high bioavailability of NK.This article briefly introduced the pharmacological properties of NK,and discussed the characteristic of different dosage forms.The development of NK preparation was prospected in order to promote its research and application.
关键词
蛋白酶/纳豆激酶/溶栓/剂型Key words
protease/nattokinase/thrombolysis/dosage form引用本文复制引用
出版年
2024
NETL
NSTL
万方数据