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前胡切片微波真空干燥特性分析及模拟

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目的 通过开展前胡切片微波真空干燥特性分析与模拟研究,探索前胡切片在微波真空干燥过程的水分及其成分变化规律,以期有效提高前胡切片的干燥效率和饮片品质。方法 进行不同干燥条件(微波功率密度、真空度和切片厚度)的前胡切片微波真空干燥实验,研究干燥过程的水分比和干燥速率变化情况,运用HPLC测定干燥后的前胡切片3个香豆素类成分(白花前胡甲素、白花前胡乙素和白花前胡素E)含量,并采用Weibull函数对干燥过程的水分比曲线进行模拟与分析。结果 前胡切片微波真空干燥过程存在加速、恒速和减速3个阶段。与真空度和切片厚度相比,通过提高微波功率密度可以更有效地缩短干燥时间、提高干燥效率。在实验参数范围内,较优干燥条件组合为微波功率密度3。0W·g-1,真空度800Pa,切片厚度2mm。所有干燥条件的变化对干燥后的前胡切片香豆素类成分含量影响均不显著。Weibull函数模拟与分析结果表明:不同干燥条件下的尺度参数为17。43~45。38,其值越小干燥时间越短,形状参数为1。41~1。77,均>1,表明干燥过程由内外部水分扩散共同控制。结论 研究工作既为前胡切片微波真空干燥的工艺改进和质量控制提供了重要的理论依据和技术支持,还将为前胡切片干燥的规范化和品质特征的形成提供重要参考。
Drying Characteristics Analysis and Simulation of Peucedani Radix Slices During Microwave Vacuum Drying
OBJECTIVE To explore the moisture and components change law of Peucedani Radix slices during microwave vacuum drying,and effectively improve the drying efficiency and slice quality of Peucedani Radix slices,by carring out drying characteristics analysis and simulation of Peucedani Radix Slices during microwave vacuum drying.METHODS Microwave vacuum drying experiments of Peucedani Radix slices under different drying conditions(microwave power density,vacuum degree and slice thickness)were carried out.The changes of moisture ratio and drying rate during drying process were studied.The contents of three coumarin ingredients(praeruptorin A,praeruptorin B and praeruptorin E)in dried Peucedani Radix slices were determined by HPLC.Weibull function was used to simulate and analyze the moisture ratio curve during drying process.RESULTS Microwave vacuum drying process of Peucedani Radix slices has three stages:acceleration,constant speed and deceleration.Compared with vacuum degree and slice thickness,increasing microwave power density could shorten drying time and improve drying efficiency more effectively.In the range of experimental parameters,the optimum drying conditions were as follows:microwave power density was 3.0 W·g-1,vacuum degree was 800 Pa,and slice thickness was 2 mm.The changes of all drying conditions had no significant effect on the content of coumarins in dried Peucedani Radix slices.The results of Weibull function simulation and analysis showed that the scale parameters under different drying conditions ranged from 17.43 to 45.38,and the smaller the value,the shorter the drying time.The shape parameters ranged from 1.41 to 1.77 and were all greater than 1,indicating that the drying process was controlled by intemal and extemal water diffusion.CONCLUSION The research work not only provides important theoretical basis and technical support for the process improvement and quality control of microwave vacuum drying process of Peucedani Radix slices,but also provides important reference for the standardization of Peucedani Radix slices drying and the formation of quality characteristics.

Peucedani Radix slicesmicrowave vacuum dryingdrying characteristicsmodelingWeibull functioncoumarin

胡轶娟、浦锦宝、徐攀、童晔玲、楼柯浪、梁卫青

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浙江省中医药研究院,杭州 310007

浙江省中药新药研发重点实验室,杭州 310007

前胡切片 微波真空干燥 干燥特性 模拟 Weibull函数 香豆素

浙江省基础公益研究计划项目浙江省中医药健康服务研究计划项目浙江省中医药科技计划中医药现代化专项项目

LGF21H2800032024ZF0472020ZX004

2024

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子:0.877
ISSN:1007-7693
年,卷(期):2024.41(10)
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