首页|IL-6在肺动脉高压中的研究进展

IL-6在肺动脉高压中的研究进展

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白细胞介素-6(interleukin-6，IL-6)是一种多效性细胞因子，在炎症反应中起重要作用。越来越多的证据表明，IL-6在肺动脉高压的发生发展中也起到了十分重要的作用，肺动脉高压患者和动物模型的循环中IL-6水平明显升高，小鼠体内过表达IL-6可以诱导重度肺动脉高压，针对IL-6的治疗可以改善肺动脉高压。本文主要从分子水平对IL-6在肺动脉高压中的作用及其机制的研究进展进行综述，并对目前以IL-6为靶点治疗肺动脉高压的候选方案进行介绍，以期为肺动脉高压的临床药物研究开发提供参考。
Advances of Interleukin-6 in Pulmonary Hypertension
Interleukin-6(IL-6)is a pleiotropic cytokine,which plays an important role in the inflammatory response.There is increasing evidence that IL-6 also plays a very important role in the development of pulmonary hypertension,as evidenced by the fact that circulating levels of IL-6 are significantly elevated in pulmonary hypertension patients and animal models,that overexpression of IL-6 in mice can induce severe pulmonary hypertension,and that treatment targeting IL-6 can improve pulmonary hypertension.This paper reviews the research progress on the role of IL-6 in pulmonary hypertension and its mechanism at the molecular level,and introduce the current candidate regimens targeting IL-6 for the treatment of pulmonary hypertension,in order to provide a reference for clinical drug research and development for pulmonary hypertension.

interleukin-6pulmonary hypertensionpulmonary arterial smooth muscle cellpulmonary vascular remodelingeffect and mechanism

陈婷婷、杨进、芦殿香

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青海大学医学院,西宁 810001

成都大学附属医院,成都 610086

白细胞介素-6 肺动脉高压 肺动脉平滑肌细胞 肺血管重塑 作用机制

青海省科技厅自然科学基金项目国家自然科学基金项目国家自然科学基金项目国家重点研发计划青海大学青年科研基金项目

2024-ZJ-94582374148820607862022YFB23032012023-QYY-5

2024

10.13748/j.cnki.issn1007-7693.20230492

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子：0.877
ISSN：1007-7693
年,卷(期)：2024.41(10)
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