Practice Guideline for Off-label Use of Immune Checkpoint Inhibitors
OBJECTIVE To provide reference for the off-label use of immune checkpoint inhibitor(ICIs),and to promote the clinical rational use of ICIs.METHODS A multi-disciplinary expert team was set up,and the practice guidelines was formed through many rounds of expert discussion on the basis of evidence-based medicine.RESULTS A total of 212 items of off-label use supported by sufficient evidence were included,including 20 items about CTL-A4 inhibitors,179 items about PD-1 inhibitors and 13 items about PD-L1 inhibitors.CONCLUSION This guide clarify the off-label use of ICIs with sufficient evidence,and provides a practical reference for ICIs off-label use management.
NETL
NSTL
万方数据
