免疫检查点抑制剂超说明书用药实践指南
Practice Guideline for Off-label Use of Immune Checkpoint Inhibitors
浙江省药学会抗肿瘤药物专业委员会 浙江省抗癌协会肿瘤临床药学专业委员会 浙江省药学会循证药学专业委员会
摘要
目的 为免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)超说明书用药提供参考,促进ICIs临床合理用药.方法 组建多学科的专家团队,在循证证据的基础上,通过多轮专家研讨,形成ICIs超说明书用药实践指南.结果 共纳入有充分循证证据支持的超说明书用药条目212条,其中CTL-A4抑制剂20条,PD-1抑制剂179条,PD-L1抑制剂13条.结论 本指南明确了循证证据充分的ICIs超说明书用药范围,为ICIs的超说明书用药管理提供了实用的参考资料.
Abstract
OBJECTIVE To provide reference for the off-label use of immune checkpoint inhibitor(ICIs),and to promote the clinical rational use of ICIs.METHODS A multi-disciplinary expert team was set up,and the practice guidelines was formed through many rounds of expert discussion on the basis of evidence-based medicine.RESULTS A total of 212 items of off-label use supported by sufficient evidence were included,including 20 items about CTL-A4 inhibitors,179 items about PD-1 inhibitors and 13 items about PD-L1 inhibitors.CONCLUSION This guide clarify the off-label use of ICIs with sufficient evidence,and provides a practical reference for ICIs off-label use management.
关键词
免疫检查点抑制剂/超说明书用药/指南Key words
immune checkpoint inhibitors/off-label use/guideline引用本文复制引用
基金项目
浙江省医药卫生科技计划项目(2023KY521)
浙江省医药卫生科技计划项目(2022KY063)
浙江省卫生高层次人才医坛新秀(浙卫办[2022]32号)
浙江省卫生高层次人才医坛新秀(浙卫办[2020]18号)
出版年
2024
NETL
NSTL
万方数据