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铁脂代谢与代谢性疾病及其天然产物防治研究进展

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铁是人体生长发育不可或缺的营养元素,对心血管具有保护作用,其丰度变化和代谢都会影响机体的生理和病理状态。目前研究证实,铁过载会促进胆固醇的合成,加重脂质代谢紊乱。体内脂质代谢紊乱易诱发相关代谢性疾病的发生与发展,并增加相关危险因素爆发的隐患。该文综述了铁脂代谢与代谢性疾病的关系及天然产物通过调节铁代谢途径防治各种疾病的机制,旨在为代谢性疾病及相关疾病机制的深入研究和靶点药物研发提供更有力的参考依据。
Overview of Iron Lipid Metabolism,Metabolic Diseases and Prevention of Natural Products
Iron is an indispensable nutritional element for human growth and development.It has a protective effect on cardiovascular.The changes and metabolism of iron can affect the physiological and pathological state of the body.Current research has confirmed that iron overload will promote the synthesis of cholesterol and increase lipid metabolism disorders.Lipid metabolic disorders in the body easily induce the occurrence and development of related metabolic diseases,and increase the hidden dangers of the outbreak of relevant risk factors.This article reviews iron and lipid metabolic and other metabolic diseases and natural products to prevent diseases through iron metabolic pathway,which aims to provide more powerful references for in-depth research on the mechanism of metabolic diseases and related diseases and target drug research and development.

iron and lipid metabolismmetabolic diseasenatural products

吴茂兰、翁家俊、曹清雨、刘亚丽、胡慧明、熊磊

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温州医科大学,浙江温州 325035

北京大学中医药临床医学院(西苑),北京 100091

南昌医学院,南昌 330052

江西省卫生健康药效与安全性评价重点实验室,南昌 330052

江西省中医药管理局抗炎类中药药效与质量评价重点研究室,南昌 330052

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铁脂代谢 代谢性疾病 天然产物

国家自然科学基金项目江西省自然科学基金项目江西省教育厅科学技术研究项目江西省教育厅科学技术研究项目

8226079420212BAB206013GJJ2203502GJJ2203521

2024

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子:0.877
ISSN:1007-7693
年,卷(期):2024.41(11)
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