Median Effective Dose of Ciprofol Combined with Sufentanil for Gastroscope in Different Populations
OBJECTIVE To test and compare the median effective dose(ED50)of ciprofol for gastroscope in patients of different genders and ages.METHODS Patients who planed to undergo gastroscope examination and treatment from March 2023 to April 2023 were selected,and divided into four groups according to stratified random method:N1 group(non-elderly male patients),N2 group(non-elderly female patients),N3 group(elderly male patients),and N4 group(elderly female patients).All patients received intravenous injection of 0.1 μg·kg-1 sufentanil followed by injection of the test dose of ciprofol according to Dixon's modified sequential method.Gastroscope was performed after the disappearance of the eyelash reflex.The initial dose of ciprofol in all four groups was 0.4 mg·kg-1,and the ratio of adjacent doses was 1∶1.1.The next patient would receive a 10％increase in the dose of ciprofol if the patient experienced positive reactions such as coughing,frowning,and body movements during the endoscopy process.Otherwise,it would be judged as a negative reaction,and the next patient would receive a 10％decrease in the dose of ciprofol.The transition from a positive reaction to a negative reaction was defined as a turning point,and the study was terminated when seven turning points occurred.Hemodynamic parameters,oxygen saturation and adverse reactions were recorded at different time points.The Probit regression analysis method was used to calculate the ED50 of ciprofol for four groups.RESULTS The ED50 of ciprofol combined with 0.1 μg·kg-1 sufentanil for gastroscope in the non-elderly men,non-elderly women,elderly men,and elderly women were 0.409,0.373,0.356,0.327 mg·kg-1,respectively.The ED50 of ciprofol in the N1 group was significantly higher compared with the N2 group and N3 group(P＜0.05).The ED50 of ciprofol in the N4 group was significantly lower compared with the N2 group and N3 group(P＜0.05).CONCLUSION The ED50 of ciprofol is significantly different among gastroscope patients of different genders and ages,which is lower in female patients than in male patients,and is lower in older patients than in non-elderly patients.
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