Effect of Sporoderm-removed Ganoderma Lucidum Spore Powder on Cancer-related Fatigue in Patients with Breast Cancer During Adjuvant Chemotherapy
OBJECTIVE To observe the preventive and therapeutic effect of Ganoderma lucidum spore powder on cancer-related fatigue in postoperative adjuvant chemotherapy patients with breast cancer,and to provide a basis for using traditional Chinese medicine processed by modem processing to effectively improve the quality of life of cancer patients.METHODS Seventy-four female patients who received postoperative adjuvant chemotherapy for breast cancer in Zhejiang Cancer Hospital from November 2021 to March 2023 were randomly divided into either treatment(n=37)or control group(n=37).Both groups were given 4 cycles of epirubicin(or liposomal doxorubicin)combined with cyclophosphamide adjuvant chemotherapy and corresponding symptomatic treatment:the treatment group was treated with sporoderm-removed Ganoderma lucidum spore powder 2 g·d-1,and the control group was treated with placebo.The incidence and severity of cancer-related fatigue,the changes in T lymphocyte subsets,serum inflammatory factors,intestinal flora,and the effects of drugs on blood routine,liver,and kidney function were compared between the two groups after treatment.RESULTS The incidence of cancer-related fatigue and the score of the Piper correction scale in the treatment group were significantly lower than those in the control group(P＜0.05),the proportion of CD3+,CD4+,and CD3-CD56+was significantly higher than that in the control group(P＜0.05),while the proportion of CD8+was significantly lower than that in the control group(P＜0.05).The counts of IL-2 and IL-10 were higher than those in the control group,while the counts of IL-6,IL-8,and CRP were lower than those in the control group(P＜0.05).The counts of leukocytes,neutrophils,and platelets in the control group were significantly higher than those in the control group(P＜0.05),and the abundance of intestinal microflora in the control group was higher than that in the control group.There was no significant difference in liver and kidney function between the 2 groups.CONCLUSION Sporoderm-removed Ganoderma lucidum spore powder can significantly reduce the incidence and level of cancer-related fatigue in breast cancer patients during adjuvant chemotherapy,inhibit inflammatory factors,regulate intestinal flora and body immunity.
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