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基于多指标-响应面法优化土炒白术的炮制工艺

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目的 对土炒白术的炮制工艺进行优化。方法 采用紫外可见分光光度法和超高效液相色谱-三重四极杆串联质谱(UPLC-QqQ-MS/MS)技术对土炒白术中多糖含量以及白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ等活性成分的含量进行测定，采用色差仪对土炒白术粉末色度值进行分析;将上述化学成分的含量以及饮片的色度作为评价指标，采用单因素试验法对土炒白术过程中的辅料用量、炒制温度、炒制时间进行考察;通过层次分析-赋值(AHP-CRITIC)混合加权法结合Box-Behnken响应面法进行土炒白术炮制工艺的优化研究。结果 优化土炒白术的最佳炮制工艺为每50 g药材用灶心土28。4 g，在204℃下炒制5。30 min。结论 本实验确定的土炒白术工艺切实可行，可为该炮制品的工业化生产提供一定的指导意义。
Process Optimization of Soil-fried Atractylodis Macrocephalae Rhizoma Based on the Multi-Index-Response Surface Method
OBJECTIVE To optimize the processing technology of soil stir-fried Atractylodis Macrocephalae Rhizoma(AMR).METHODS UV-visible spectrophotometry and ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-QqQ-MS/MS)was used to determine the content of polysaccharides and active ingredients such as atractylenolide Ⅰ,atractylenolide Ⅱ,atractylenolide Ⅲ,etc.The colorimeter was used to determine the color value of soil-fried AMR powder.The contents of the above chemical components and the color value of soil-fried AMR were used as evaluation indexes.The single factor trial method was adopted to investigate the amount of excipients,stir-frying temperature and time of AMR.The analytic hierarchy process and criteria importance through inter criteria correlation(AHP-CRITIC)combined with the method of Box-Behnken response surface was used to design and optimize the processing technology of soil stir-fried AMR.RESULTS The best processing technology of soil fried AMR were optimized to 28.4 g of soil added to 50 g of medicinal materials which was fried 5.30 min in 204 ℃.CONCLUSION The process of soil stir-fried AMR determined in this experiment is feasible which can provide certain guiding significance for the industrial production of the processed products.

Atractylodis Macrocephalae Rhizomasoil-friedmixed weighting methodBox-Behnken response surface methodprocess optimization

袁楚、刘想、高如汐、王凡一、张可、吴昊、刘思奇、赵启苗、单国顺

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辽宁中医药大学,辽宁大连 116600

辽宁医药职业学院,沈阳 110101

白术 土炒 混合加权法 Box-Behnken响应面法 工艺优化

国家自然科学基金青年基金项目辽宁省教育厅面上项目辽宁省教育厅面上项目辽宁中医药大学校级课题重点项目辽宁医药职业学院校级课题

81803726LJKMZ20222205LJKMZ202213082021LZY054BSKY202405

2024

10.13748/j.cnki.issn1007-7693.20241505

中国现代应用药学
中国药学会

中国现代应用药学

CSTPCD北大核心
影响因子：0.877
ISSN：1007-7693
年,卷(期)：2024.41(14)