基于响应面法结合熵权法优化浙贝母(灰贝)加工工艺
Optimization of Fritillariae Thunbergii Bulbus(Huibei)Processing Technology Based on Response Surface Method Combined with Entropy Weight Method
李莉 1杨先启 1陈军 1张叶峰 2邵将炜3
作者信息
- 1. 宁波市药品检验所,浙江宁波 315048
- 2. 宁波市中药饮片有限公司,浙江宁波 315336
- 3. 宁波小贝农农业科技有限公司,浙江宁波 315000
- 折叠
摘要
目的 应用响应面法结合熵权法优化浙贝母(灰贝)的加工工艺.方法 以伊贝辛、贝母辛、贝母素甲、贝母素乙、异贝母甲素为考察指标,熵权法确定各指标成分权重,在单因素试验的基础上,采用Box-Behnken响应面法设计优化浙贝母(灰贝)的加工工艺.结果 得到最优提取工艺为撞皮时间95 s、料灰比0.9％、发汗时间5 h、干燥温度45℃,验证结果与预测值偏差为0.5％.结论 响应面法优选的加工工艺稳定性好,可操作性强,可为浙贝母(灰贝)产地加工炮制一体化的质量控制提供科学依据.
Abstract
OBJECTIVE To optimize the processing technology of Fritillariae Thunbergii Bulbus(Huibei)by response surface methodology combined with entropy weight method.METHODS The single factor experiment combined with Box-Behnken design was used to optimize the processing technology,with 5 kinds of alkaloid(yibeissine,peimisine,peimine,peiminine,isobeta metrin)as the inspection indicators,combined with the weight coefficients were calculated by entropy weight method.RESULTS The optimum extraction process was determined as follows:crashing time for 95 seconds,material-to-ash ratio for 0.9％,sweating time for 5 h,and drying temperature for 45 ℃.The RSD between the validation results and the predicted values was 0.5％.CONCLUSION This optimized processing technology is stable amd feasible,which can provide the scientific basis for quality control of Fritillariae Thunbergii Bulbus(Huibei)processing technology.
关键词
浙贝母(灰贝)/响应面法/加工工艺/生物碱/熵权法Key words
Fritillariae Thunbergii Bulbus(Huibei)/response surface method/processing technology/alkaloids/entropy weight method引用本文复制引用
基金项目
国家药品监督管理局药品监管科学体系建设重点项目(RS2024Z006)
出版年
2024
NETL
NSTL
万方数据